| Player | College | MLB Team | 2020 Overall Pick | Pos |
| Corbin Carroll | 0 | Arizona Diamondbacks | 0 | 0 |
| Kristian Robinson | 0 | Arizona Diamondbacks | 0 | 0 |
| Bryce Jarvis | Duke | Arizona Diamondbacks | 18 | RHP |
| Slade Cecconi | Miami | Arizona Diamondbacks | 33 | RHP |
| Liam Norris | Green Hope High School (North Carolina) | Arizona Diamondbacks | 90 | LHP |
| A.J. Vukovich | East Troy High School (Wisconsin) | Arizona Diamondbacks | 119 | 3B |
| Brandon Pfaadt | Bellarmine University | Arizona Diamondbacks | 149 | RHP |
| Ian Anderson | 0 | Atlanta Braves | 0 | 0 |
| Drew Waters | 0 | Atlanta Braves | 0 | 0 |
| Cristian Pache | 0 | Atlanta Braves | 0 | 0 |
| Jared Shuster | Wake Forest | Atlanta Braves | 25 | LHP |
| Jesse Franklin | Michigan | Atlanta Braves | 97 | OF |
| Spencer Strider | Clemson | Atlanta Braves | 126 | RHP |
| Ryan Mountcastle | 0 | Baltimore Orioles | 0 | 0 |
| Rylan Bannon | 0 | Baltimore Orioles | 0 | 0 |
| Heston Kjerstad | Arkansas | Baltimore Orioles | 2 | OF |
| Jordan Westburg | Mississippi State | Baltimore Orioles | 30 | SS |
| Hudson Haskin | Tulane | Baltimore Orioles | 39 | OF |
| Anthony Servideo | Ole Miss | Baltimore Orioles | 74 | SS |
| Carter Baumler | Dowling Catholic High School (Iowa) | Baltimore Orioles | 133 | RHP |
| Thomas Girard | Duke | Baltimore Orioles | UDFA | RHP |
| Triston Casas | 0 | Boston Red Sox | 0 | 0 |
| Bobby Dalbec | 0 | Boston Red Sox | 0 | 0 |
| Jarren Duran | 0 | Boston Red Sox | 0 | 0 |
| Bryan Mata | 0 | Boston Red Sox | 0 | 0 |
| Tanner Houck | 0 | Boston Red Sox | 0 | 0 |
| Nick Yorke | Archbishop Mitty High School (California) | Boston Red Sox | 17 | 2B |
| Jeremy Wu-Yelland | Hawaii | Boston Red Sox | 118 | LHP |
| Shane Drohan | Florida State | Boston Red Sox | 148 | LHP |
| Jordan DiValerio | Saint Joseph’s | Boston Red Sox | UDFA | RHP |
| Miguel Amaya | 0 | Chicago Cubs | 0 | 0 |
| Ed Howard | Mount Carmel High School (Illinois) | Chicago Cubs | 16 | SS |
| Burl Carraway | Dallas Baptist (Texas) | Chicago Cubs | 51 | LHP |
| Jordan Nwogu | Michigan | Chicago Cubs | 88 | OF |
| Luke Little | San Jacinto College North (Texas) | Chicago Cubs | 117 | LHP |
| Bradlee Beesley | Cal Poly | Chicago Cubs | UDFA | OF |
| Dane Dunning | Florida | Chicago White Sox | 0 | 0 |
| Jordan Mikel | Illinois-Springfield | Chicago White Sox | 0 | 0 |
| Andrew Vaughn | 0 | Chicago White Sox | 0 | 0 |
| Norge Vera | 0 | Chicago White Sox | 0 | 0 |
| Garrett Crochet | Tennessee | Chicago White Sox | 11 | LHP |
| Jared Kelley | Refugio High School (Texas) | Chicago White Sox | 47 | RHP |
| Adisyn Coffey | Wabash Valley College | Chicago White Sox | 83 | RHP |
| Kade Mechals | Grand Canyon University | Chicago White Sox | 112 | RHP |
| Bailey Horn | Auburn | Chicago White Sox | 142 | LHP |
| Hunter Greene | 0 | Cincinnati Reds | 0 | 0 |
| Austin Hendrick | West Allegheny High School (Pennsylvania) | Cincinnati Reds | 12 | OF |
| Christian Roa | Texas A&M | Cincinnati Reds | 48 | RHP |
| Jackson Miller | J.W. Mitchell High School (Florida) | Cincinnati Reds | 65 | C |
| Bryce Bonnin | Texas Tech | Cincinnati Reds | 84 | RHP |
| Mac Wainwright | St. Edwards High School (Ohio) | Cincinnati Reds | 113 | OF |
| Joe Boyle | Notre Dame | Cincinnati Reds | 143 | RHP |
| Gus Steiger | South Dakota State | Cincinnati Reds | UDFA | INF |
| Logan T. Allen | Florida International | Cleveland Indians | 0 | 0 |
| Triston McKenzie | 0 | Cleveland Indians | 0 | 0 |
| Tyler Freeman | 0 | Cleveland Indians | 0 | 0 |
| Nolan Jones | 0 | Cleveland Indians | 0 | 0 |
| Carson Tucker | Mountain Pointe High School (Arizona) | Cleveland Indians | 23 | SS |
| Tanner Burns | Auburn | Cleveland Indians | 36 | RHP |
| Petey Halpin | Mira Costa High School (California) | Cleveland Indians | 95 | OF |
| Milan Tolentino | Santa Margarita High School (California) | Cleveland Indians | 124 | SS |
| Mason Hickman | Vanderbilt | Cleveland Indians | 154 | RHP |
| Zac Veen | Spruce Creek High School (Florida) | Colorado Rockies | 9 | OF |
| Drew Romo | The Woodlands High School (Texas) | Colorado Rockies | 35 | C |
| Sam Weatherly | Clemson | Colorado Rockies | 81 | LHP |
| Case Williams | Douglas County High School (Colorado) | Colorado Rockies | 110 | RHP |
| Jack Blomgren | Michigan | Colorado Rockies | 140 | SS |
| Matt Manning | 0 | Detroit Tigers | 0 | 0 |
| Riley Greene | 0 | Detroit Tigers | 0 | 0 |
| Tarik Skubal | 0 | Detroit Tigers | 0 | 0 |
| Isaac Paredes | 0 | Detroit Tigers | 0 | 0 |
| Spencer Torkelson | Arizona State | Detroit Tigers | 1 | 3B |
| Dillon Dingler | Ohio State | Detroit Tigers | 38 | C |
| Daniel Cabrera | LSU | Detroit Tigers | 62 | OF |
| Trei Cruz | Rice | Detroit Tigers | 73 | SS |
| Gage Workman | Arizona State | Detroit Tigers | 102 | 3B |
| Colten Keith | Biloxi High School (Mississippi) | Detroit Tigers | 132 | 3B |
| Freudis Nova | 0 | Houston Astros | 0 | 0 |
| Alex Santos | Mt. Saint Michael Academy (New York) | Houston Astros | 72 | RHP |
| Tyler Brown | Vanderbilt | Houston Astros | 101 | RHP |
| Zach Daniels | Tennessee | Houston Astros | 131 | OF |
| Yoelqui Cespedes | 0 | International | 0 | 0 |
| Oscar Colas | 0 | International | 0 | 0 |
| Brady Singer | Florida | Kansas City Royals | 0 | 0 |
| Erick Pena | 0 | Kansas City Royals | 0 | 0 |
| Bobby Witt Jr. | 0 | Kansas City Royals | 0 | 0 |
| A.J. Block | 0 | Kansas City Royals | 0 | 0 |
| Daniel Lynch | 0 | Kansas City Royals | 0 | 0 |
| Asa Lacy | Texas A&M | Kansas City Royals | 4 | LHP |
| Nick Loftin | Baylor | Kansas City Royals | 32 | SS |
| Ben Hernandez | De La Salle Institute (Illinois) | Kansas City Royals | 41 | RHP |
| Tyler Gentry | Alabama | Kansas City Royals | 76 | OF |
| Will Klein | Eastern Illinois | Kansas City Royals | 135 | RHP |
| Kale Emshoff | Arkansas-Little Rock | Kansas City Royals | UDFA | C |
| Reid Detmers | Louisville | Los Angeles Angels | 10 | LHP |
| David Calabrese | St. Elizabeth Catholic High School (Ontario) | Los Angeles Angels | 82 | OF |
| Werner Blakely | Detroit Edison High School (Michigan) | Los Angeles Angels | 111 | SS |
| Adam Seminaris | Long Beach State | Los Angeles Angels | 141 | LHP |
| Luis Rodriguez | 0 | Los Angeles Dodgers | 0 | 0 |
| Hyun-il Choi | 0 | Los Angeles Dodgers | 0 | 0 |
| Bobby Miller | Louisville | Los Angeles Dodgers | 29 | RHP |
| Landon Knack | East Tennessee State | Los Angeles Dodgers | 60 | RHP |
| Clayton Beeter | Texas Tech | Los Angeles Dodgers | 66 | RHP |
| Jake Vogel | Huntington Beach High School (California) | Los Angeles Dodgers | 100 | OF |
| Carson Taylor | Virginia Tech | Los Angeles Dodgers | 130 | C |
| Gavin Stone | Central Arkansas | Los Angeles Dodgers | 159 | RHP |
| JJ Bleday | 0 | Miami Marlins | 0 | 0 |
| Jesus Sanchez | 0 | Miami Marlins | 0 | 0 |
| Jose Salas | 0 | Miami Marlins | 0 | 0 |
| Yiddi Cappe | 0 | Miami Marlins | 0 | 0 |
| Max Meyer | Minnesota | Miami Marlins | 3 | RHP |
| Dax Fulton | Mustang High School (Oklahoma) | Miami Marlins | 40 | LHP |
| Kyle Nicolas | Ball State | Miami Marlins | 61 | RHP |
| Zach McCambley | Coastal Carolina | Miami Marlins | 75 | RHP |
| Jake Eder | Vanderbilt | Miami Marlins | 104 | LHP |
| Kyle Hurt | USC | Miami Marlins | 134 | RHP |
| Drew Rasmussen | 0 | Milwaukee Brewers | 0 | 0 |
| Brice Turang | 0 | Milwaukee Brewers | 0 | 0 |
| Tristen Lutz | 0 | Milwaukee Brewers | 0 | 0 |
| Garrett Mitchell | UCLA | Milwaukee Brewers | 20 | OF |
| Freddy Zamora | Miami | Milwaukee Brewers | 53 | SS |
| Zavier Warren | Central Michigan | Milwaukee Brewers | 92 | C |
| Joey Wiemer | Cincinnati | Milwaukee Brewers | 121 | OF |
| Hayden Cantrelle | University of Louisiana at Lafayette | Milwaukee Brewers | 151 | SS |
| Travis Blankenhorn | 0 | Minnesota Twins | 0 | 0 |
| Alex Kirilloff | 0 | Minnesota Twins | 0 | 0 |
| Aaron Sabato | UNC | Minnesota Twins | 27 | 1B |
| Alerick Soularie | Tennessee | Minnesota Twins | 59 | OF |
| Marco Raya | United South High School (Texas) | Minnesota Twins | 128 | RHP |
| Kala’i Rosario | Waiakea High School (Hawaii) | Minnesota Twins | 158 | OF |
| Andres Gimenez | 0 | New York Mets | 0 | 0 |
| Pete Crow-Armstrong | Harvard-Westlake School (California) | New York Mets | 19 | OF |
| Isaiah Greene | Corona Senior High School (California) | New York Mets | 69 | OF |
| Anthony Walters | San Diego State | New York Mets | 91 | SS |
| Matthew Dyer | Arizona | New York Mets | 120 | C |
| Eric Orze | University of New Orleans | New York Mets | 150 | RHP |
| Clay Aguilar | 0 | New York Yankees | 0 | 0 |
| Estevan Florial | 0 | New York Yankees | 0 | 0 |
| Austin Wells | Arizona | New York Yankees | 28 | C |
| Trevor Hauver | Arizona State | New York Yankees | 99 | LF |
| Beck Way | Northwest Florida State | New York Yankees | 129 | RHP |
| Tyler Soderstrom | Turlock High School (California) | Oakland A’s | 26 | C |
| Jeff Criswell | Michigan | Oakland A’s | 58 | RHP |
| Michael Guldberg | Georgia Tech | Oakland Athletics | 98 | OF |
| Dane Acker | Oklahoma | Oakland Athletics | 127 | RHP |
| Stevie Emanuels | Washington | Oakland Athletics | 157 | RHP |
| Spencer Howard | 0 | Philadelphia Phillies | 0 | 0 |
| Johan Rojas | 0 | Philadelphia Phillies | 0 | 0 |
| Luis Garcia | 0 | Philadelphia Phillies | 0 | 0 |
| Mick Abel | Jesuit High School (Oregon) | Philadelphia Phillies | 15 | RHP |
| Casey Martin | Arkansas | Philadelphia Phillies | 87 | SS |
| Baron Radcliff | Georgia Tech | Philadelphia Phillies | 146 | OF |
| Chase Antle | Coastal Carolina | Philadelphia Phillies | UDFA | RHP |
| Ji-Hwan Bae | 0 | Pittsburgh Pirates | 0 | 0 |
| Oneil Cruz | 0 | Pittsburgh Pirates | 0 | 0 |
| Mason Martin | 0 | Pittsburgh Pirates | 0 | 0 |
| Nick Gonzales | New Mexico State | Pittsburgh Pirates | 7 | SS |
| Carmen Mlodzinski | South Carolina | Pittsburgh Pirates | 31 | RHP |
| Jared Jones | La Miranda High School (California) | Pittsburgh Pirates | 44 | RHP |
| Nick Garcia | Chapman University | Pittsburgh Pirates | 79 | RHP |
| Jack Hartman | Appalachian State | Pittsburgh Pirates | 108 | RHP |
| Logan Hofmann | Northwestern State | Pittsburgh Pirates | 138 | RHP |
| CJ Abrams | 0 | San Diego Padres | 0 | 0 |
| MacKenzie Gore | 0 | San Diego Padres | 0 | 0 |
| Robert Hassell | Independence High School (Tennessee) | San Diego Padres | 8 | OF |
| Justin Lange | Llano High School (Texas) | San Diego Padres | 34 | RHP |
| Owen Caissie | Notre Dame Catholic (Ontario) | San Diego Padres | 45 | OF |
| Levi Thomas | Troy | San Diego Padres | 109 | RHP |
| Joey Bart | Georgia Tech | San Francisco Giants | 0 | 0 |
| Heliot Ramos | 0 | San Francisco Giants | 0 | 0 |
| Patrick Bailey | NC State | San Francisco Giants | 13 | C |
| Casey Schmitt | San Diego State | San Francisco Giants | 49 | 3B |
| Nick Swiney | NC State | San Francisco Giants | 67 | LHP |
| Jimmy Glowenke | Dallas Baptist | San Francisco Giants | 68 | SS |
| R.J. Dabovich | Arizona State | San Francisco Giants | 114 | RHP |
| Brett Auerbach | Alabama | San Francisco Giants | UDFA | C |
| Jarred Kelenic | 0 | Seattle Mariners | 0 | 0 |
| Evan White | 0 | Seattle Mariners | 0 | 0 |
| Noelvi Marte | 0 | Seattle Mariners | 0 | 0 |
| Julio Rodriguez | 0 | Seattle Mariners | 0 | 0 |
| Emerson Hancock | Georgia | Seattle Mariners | 6 | RHP |
| Zach DeLoach | Texas A&M | Seattle Mariners | 43 | OF |
| Connor Phillips | McLennan CC (Texas) | Seattle Mariners | 64 | RHP |
| Kaden Polcovich | Oklahoma State | Seattle Mariners | 78 | 2B |
| Tyler Keenan | Ole Miss | Seattle Mariners | 107 | 3B |
| Taylor Dollard | Cal Poly | Seattle Mariners | 137 | RHP |
| Justin Lavey | Louisville | Seattle Mariners | UDFA | SS/3B |
| Matt Scheffler | Auburn | Seattle Mariners | UDFA | C |
| Matthew Liberatore | 0 | St. Louis Cardinals | 0 | 0 |
| Nolan Gorman | 0 | St. Louis Cardinals | 0 | 0 |
| Dylan Carlson | 0 | St. Louis Cardinals | 0 | 0 |
| Jordan Walker | Decatur High School (Georgia) | St. Louis Cardinals | 21 | 3B |
| Masyn Winn | Kingwood High School (Texas) | St. Louis Cardinals | 54 | SS |
| Markevian Hence | Watson Chapel High School (Arkansas) | St. Louis Cardinals | 63 | RHP |
| Alec Burleson | ECU | St. Louis Cardinals | 70 | 1B |
| Levi Prater | Oklahoma | St. Louis Cardinals | 93 | LHP |
| Ian Bedell | Missouri | St. Louis Cardinals | 122 | RHP |
| LJ Jones | Long Beach State | St. Louis Cardinals | 152 | OF |
| Wander Franco | 0 | Tampa Bay Rays | 0 | 0 |
| Shane Baz | 0 | Tampa Bay Rays | 0 | 0 |
| Nick Bitsko | Central Bucks High School East (Pennsylvania) | Tampa Bay Rays | 24 | RHP |
| Alika Williams | Arizona State | Tampa Bay Rays | 37 | SS |
| Ian Seymour | Virginia Tech | Tampa Bay Rays | 57 | LHP |
| Hunter Barnhart | St. Joseph High School (California) | Tampa Bay Rays | 96 | RHP |
| Tanner Murray | UC Davis | Tampa Bay Rays | 125 | SS |
| Jeff Hakanson | Central Florida | Tampa Bay Rays | 155 | RHP |
| Josh Jung | 0 | Texas Rangers | 0 | 0 |
| Luisangel Acuna | 0 | Texas Rangers | 0 | 0 |
| Zion Bannister | 0 | Texas Rangers | 0 | 0 |
| Justin Foscue | Mississippi State | Texas Rangers | 14 | 2B |
| Evan Carter | Elizabethton High School (Tennessee) | Texas Rangers | 50 | OF |
| Tekoah Roby | Pine Forest High School (Florida) | Texas Rangers | 86 | RHP |
| Dylan MacLean | Central Catholic High School | Texas Rangers | 115 | LHP |
| Nate Pearson | 0 | Toronto Blue Jays | 0 | 0 |
| Austin Martin | Vanderbilt | Toronto Blue Jays | 5 | SS |
| CJ Van Eyk | Florida State | Toronto Blue Jays | 42 | RHP |
| Trent Palmer | Jacksonville University | Toronto Blue Jays | 77 | RHP |
| Nick Frasso | Loyola Marymount University | Toronto Blue Jays | 106 | RHP |
| Zach Britton | Louisville | Toronto Blue Jays | 136 | OF |
| Luis V. Garcia | 0 | Washington Nationals | 0 | 0 |
| Cade Cavalli | Oklahoma | Washington Nationals | 22 | RHP |
| Cole Henry | LSU | Washington Nationals | 55 | RHP |
| Sammy Infante | Monsignor Edward Pace High School | Washington Nationals | 71 | SS |
| Holden Powell | UCLA | Washington Nationals | 94 | RHP |
| Brady Lindsly | Oklahoma | Washington Nationals | 123 | C |
| Mitchell Parker | San Jacinto College North | Washington Nationals | 153 | LHP |
| Jackson Coutts | Rhode Island | Washington Nationals | UDFA | 1B/OF |